Fort Stoddert was established in 1799 on the Mobile River near the boundary between the Mississippi Territory and Spanish West Florida. The fort was for a time a port of entry to United States territory, but
is most well known as the western terminus of the Federal Road connecting central Georgia with the Tensaw District. The fort, along with the nearby post at Mount Vernon, served as the central command
center for military actions in the Tensaw region during the Creek War, as well as a place of refuge for settlers who fled the area in the wake of the attack on Fort Mims.

An historic marker commemorating Fort Stoddert stands alongside Highway 43 in the area of the modern communities of Mt. Vernon and Fort Stoddard in northern Mobile County, Alabama. The actual
fort site, near a landing on Mobile River, is located three miles east of the marker on County Road 96. The exact location is unmarked.